Artúr Beke (ed.)

Genetic background of gynecological diseases

Rare gynecological diseases with genetic origin

Hereditary breast and ovarian cancer syndrome

Breast cancer is a common tumor type, in developed countries, the average risk of a woman developing breast cancer sometime in her life is about 12%. However, overall, only 10% of all cases have a familial appearance. Hereditary breast and ovarian cancer is mostly associated with mutations in BRCA1 gene (BRCA1 DNA Repair Associated) and BRCA2 gene (BRCA2 DNA Repair Associated), both genes are tumor suppressor genes. In approximately 50% of the familial cases, the genetic background cannot be revealed, and 50% of another half of the familial cases can be described by pathogenic/likely pathogenic BRCA1 gene or BRCA2 gene variants.

Genetic background of gynecological diseases

Tartalomjegyzék

Kiadó: Akadémiai Kiadó

Online megjelenés éve: 2024

ISBN: 978 963 664 024 8

Orvostudomány

Our book was written with the intention of filling a gap. It is the work of specialists - university lecturers, researchers, clinicians - who come across the described symptoms in their daily practice.

Many previously published publications deal with the gynecological pathologies discussed in the volume, but from the perspective of genetics as an etiological factor, focusing on the genetic background of pathological conditions and women's diseases, no book has yet been published. Nowadays, science is developing rapidly, and almost all diseases are subjected to genetic testing during research. For this reason, only those pathologies will be presented for which the tests so far have clearly confirmed the genetic background, that is, those pathologies for which the possibility of a genetic cause has arisen, but cannot yet be clearly proven, do not form the material of the book.

We recommend the book primarily to health professionals, geneticists, obstetricians and gynecologists, pedoatric gynecologists, and pediatricians, and those preparing for special exams. Medical students and midwifery students interested in the topic can find important information in it, and it can also be useful for "non-specialists".

Hivatkozás: https://mersz.hu/beke-genetic-background-of-gynecological-diseases//

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