Artúr Beke (ed.)

Genetic background of gynecological diseases

Rare gynecological diseases with genetic origin

Hereditary nonpolyposis colorectal cancer (HNPCC, Lynch syndrome) and gynecological tumors

The Lynch syndrome (hereditary nonpolyposis colorectal cancer, HNPCC) is the most common hereditary type of colorectal cancer. The population prevalence of Lynch syndrome has been found variable; however, it is estimated to account for approximately 1,9-15% of colorectal cancer cases. The risk and age of developing cancer varies depending on the gene involved; however, the onset of cancer starts at an earlier age compared to the control population. The risk of colorectal cancer before the age of 50 is 180 times higher in men, and 100 times higher in women than in the general population. Regarding gynecological malignancies, endometrial cancer develops in 60%, ovarian cancer occurs in 12% of Lynch syndrome patients besides other tumor types (such as stomach, small bowel, liver and and biliary tract, and urinary tract cancer).

Genetic background of gynecological diseases

Tartalomjegyzék

Kiadó: Akadémiai Kiadó

Online megjelenés éve: 2024

ISBN: 978 963 664 024 8

Orvostudomány

Our book was written with the intention of filling a gap. It is the work of specialists - university lecturers, researchers, clinicians - who come across the described symptoms in their daily practice.

Many previously published publications deal with the gynecological pathologies discussed in the volume, but from the perspective of genetics as an etiological factor, focusing on the genetic background of pathological conditions and women's diseases, no book has yet been published. Nowadays, science is developing rapidly, and almost all diseases are subjected to genetic testing during research. For this reason, only those pathologies will be presented for which the tests so far have clearly confirmed the genetic background, that is, those pathologies for which the possibility of a genetic cause has arisen, but cannot yet be clearly proven, do not form the material of the book.

We recommend the book primarily to health professionals, geneticists, obstetricians and gynecologists, pedoatric gynecologists, and pediatricians, and those preparing for special exams. Medical students and midwifery students interested in the topic can find important information in it, and it can also be useful for "non-specialists".

Hivatkozás: https://mersz.hu/beke-genetic-background-of-gynecological-diseases//

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